This does not necessarily apply to golden chests randomly generated by items effects.

You do not need to pick up the item that spawns after the Mom fight: Isaac will always be transported to the Chest after touching the golden chest that spawns in the Cathedral even if it doesn't seem like he has The Polaroid on him.

All glitched items will appear as the icon for Mega Blast in the pause menu and death screen, though will keep their original glitched appearance on the Extra HUD.

The blank space where the invisible challenge is located still gets crossed out after the challenge is complete, however.

Unlike all other challenges, DELETE THIS appears below the challenge list itself, as an additional nameless challenge not numbered on the list.

Or an item that grants a black heart whenever damage is taken which makes Isaac functionally invincible and causing mass damage whenever touched. Such as an active item with no charges, and deals damage to the whole room which can be spammed to clear each room.

Due to the random nature of generated items, it is possible to find an item that makes completing the challenge trivial.

Conversely, it is possible for the challenge to have effects rendering it impossible, such as by destroying the ending trophy, or the challenge ending with a seeming victory but gaining no completion mark.

It is possible for the challenge to be completed early if an item happens to spawn the ending trophy.

Waiting for an Angel Room to spawn instead is a safer strategy.

Taking a Deal with the Devil should only be done when having strong life bar: You have no guarantee to get a good item, so you might lose heart containers for nothing.

Try to finish the challenge as fast as possible, as a game crash is always randomly likely to happen from picking up just one item.

Once you have a reliable strategy, stop taking items, as some of their effects (replicating Damocles or mass spawning enemies) can end the run.

As such, Bombs and XIII - Death gain increased utility during this challenge, as their relatively high damage is unaffected by randomization.

Due to the inherent random nature of items, direct stat ups are very rare.

Trinkets, Pills, Cards and Runes are unaffected by the randomization that TMTRAINER forces on other types of items finding good trinkets such as Curved Horn or Cancer, as well as saving powerful cards such as XIX - The Sun for bad situations, can help give advantages despite your lower-than-usual stats.

Item prices in shops can vary significantly, from as low as a single cent to as high as 99 cents.

Be warned, as items are randomly generated, active items could also just damage the player.

Try to get an active item that has a low charge or does something beneficial.

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